"The greatest Greek city and most beautiful of them all" is how Cicero described Syracuse, once the largest city in the ancient world. Travel back in time on the island of Ortygia, where Syracuse was founded by the Greeks in 734 BC. Nearly 3,000 years later, this UNESCO site is one of Sicily's greatest archaeological treasures. In between spectacular ancient relics, treat your palate to cheese, olives and cured meats from street vendors or delicious gelato from a gelateria. Looming in the distance is Sicily's most famous attraction, Mt. Etna, which nourishes the rich soils that produce some of the best wines, fruits and nuts in the world.